an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

sharp chest pain, coughing blood or sudden shortness of breath (possible blood clot in the lung);

pain in the calf (possible blood clot in the leg);

crushing chest pain or heaviness in the chest (possible heart attack);

sudden severe headache or vomiting, dizziness, faintness or problems with vision or speech, weakness or numbness in an arm or leg (possible stroke);

yellowing of the skin or whites of the eyes (jaundice), especially with fever, tiredness, loss of appetite, dark colored urine, or light colored bowel movements (possible liver problems);

sudden partial or complete loss of vision (possible clot in the eye);

severe pain, swelling, or tenderness in the abdomen (gallbladder or liver problems);

irregular vaginal bleeding or spotting that happens in more than 1 menstrual cycle or lasts for more than a few days;

swelling (edema) of the fingers or ankles; or

severe problems with difficulty sleeping, weakness, lack of energy, fatigue, or a change in mood (possible severe depression).

new or changing breast lumps